Substratos de FTases e Proteínas Relacionadas
Since the initial discovery of farnesylated fungal proteins, many more proteins have been demonstrated to contain a prenyl modification. Today it's well-known, that protein prenylation affects up to 2% of the proteins in the mammalian proteome.
The proteins listed below are FTase substrates and corresponding proteins.
A farnesyl moiety is attached to the cysteine of the so called CaaX box, a C-terminal motif required for farnesylation.
Please note that deletion mutants with truncated C-terminus are not recognized by the protein farnesyltransferase and will thus not be farnesylated.
Produtos
H-Ras ΔC (S17N) PR-202
Harvey rat sarcoma viral oncogene homolog, residues 1-166
human, recombinant, E. coli
M-Ras/R-Ras3His (Q71L) PR-396
muscle and microspikes Ras, related ras viral oncogene homolog 3
human, recombinant, E. coli
TC21/R-Ras2GST PR-359
Teratocarcinoma oncogene, related ras viral oncogene homolog 2
human, recombinant, E. coli