Nucleotídeos Citostáticos

Table 1: Available cytostatic nucleosides and corresponding nucleotide variants.

Nucleoside	Nucleotide Monophosphate (NMP)	Nucleotide Diphosphate (NDP)	Nucleotide Triphosphate (NTP)
ara-A (Vidarabine)	ara-AMP		ara-ATP
Cl-F-ara-A (Clofarabine)	Cl-F-ara-AMP		Cl-F-ara-ATP
2'Cl-Adenosine			2'Cl-dATP
ara-C (Cytarabine)	ara-CMP	ara-CDP	ara-CTP
dF-dC (Gemcitabine)	dF-dCMP	dF-dCDP	dF-dCTP
5F-U (5-Fluoruracil)	5F-dUMP		5F-dUTP
6-Thio-I (6-Thio-inosine)	6-Thio-IMP	6-Thio-IDP	6-Thio-ITP
6-Methylthio-I (6-Methylthio-inosine)	6-Methylthio-IMP	6-Methylthio-IDP	6-Methylthio-ITP
5-Aza-dC (Decitabine)			5-Aza-dCTP

Produtos

ara-Adenosine-5'-monophosphate (ara-AMP) NU-875

Vidarabine monophosphate, Sodium salt

ara-Adenosine-5'-triphosphate (ara-ATP) NU-1111

Vidarabine triphosphate, Sodium Salt

Clofarabine-5'-monophosphate NU-873

Triethylammonium salt

Clofarabine-5'-triphosphate NU-874

Triethylammonium salt

2'-Chloro-dATP NU-148

(2'Cl-dATP)

ara-Cytidine-5'-monophosphate (ara-CMP) NU-872

Cytarabine monophosphate, Sodium salt

ara-Cytidine-5'-diphosphate (ara-CDP) NU-1171

Cytarabine diphosphate

ara-Cytidine-5'-triphosphate (ara-CTP) NU-1170

Cytarabine triphosphate, Sodium salt

Gemcitabine-5'-monophosphate NU-871

Sodium salt

Gemcitabine-5'-diphosphate NU-1608

Sodium Salt

Gemcitabine-5'-triphosphate NU-1607

Sodium Salt

5-Fluoro-dUMP NU-153

(5F-dUMP)

5-Fluoro-dUTP NU-154

(5F-dUTP)

6-Mercaptopurine-riboside-5'-monophosphate NU-1148

6-Thio-Inosine-5'-monophosphate

6-Mercaptopurine-riboside-5'-diphosphate NU-1210

6-Thio-inosine-5'-diphosphate

6-Mercaptopurine-riboside-5'-triphosphate NU-1110

6-Thio-Inosine-5'-triphosphate

6-Methylthio-IMP NU-1131

6-Methylthio-IDP NU-1132

6-Methylthio-ITP NU-1133

5-Aza-dCTP NU-1118

Decitabine triphosphate

Selected References

[1] Hanahan et al. (2011) Hallmarks of Cancer: The next generation. Cell 144 (5):646.