Clofarabine-5'-triphosphate

For general laboratory use.

Envio: shipped on gel packs

Condições de armazenamento: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Validade: 12 months after date of delivery

Fórmula molecular: C10H14ClFN5O12P3 (free acid)

Peso molecular: 543.62 g/mol (free acid)

CAS#: 167620-89-5

Pureza: ≥ 95 % (HPLC)

Forma: oil

Propriedades espectroscópicas: λmax 262 nm, ε 14.3 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Referências selecionadas:
Nagai et al. (2011) Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity. Cancer Res 71 (5):1781.

Yamauchi et al. (2001) DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine. Clinical Cancer Research 7 (11):3580.

Parker et al. (1991) Effects of 2-chloro-9- (2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate. Cancer Research 51 (9):2386.