UTP - Solution

For general laboratory use.

Envio: shipped on gel packs

Condições de armazenamento: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible. If stored as recommended, Jena Bioscience guarantees optimal performance of this product for 12 months after date of delivery.

Validade: 12 months

Fórmula molecular: C9H15N2O15P3 (free acid)

Peso molecular: 484.14 g/mol (free acid)

CAS#: 19817-92-6

Pureza: ≥ 99 % (HPLC)

Forma: clear aqueous solution

Concentração: 100 mM ±2 %

pH: 8.0 ±0.2 (22 °C)

Propriedades espectroscópicas: λmax 262 nm, ε 9.8 L mmol-1 cm-1 (Tris-HCl pH 7.0)

Formulários:
Activation of purinergic receptors^[1,2,3,4]
Cardioprotection against hypoxic damage^[2]
Enzyme kinetic parameters^[5]
Phosphorylation of EGF-receptor vie purinergic receptors^[3]
Stimulation of neurogenesis and dopaminergic neurons^[6]

Descrição:
Ultrapure UTP supplied as clear aqueous solution.

Specific Ligands: Enterovirus 71 3D RNA polymerase[7] Ligand for purinergic receptors: P2X1[4] P2Y2[7,8,9,10] P2Y4[8,10,11] P2Y6[8]

Referências selecionadas:
[1] Raqeeb et al. (2011) Purinergic P2Y2 receptors mediate rapid Ca2+ mobilization, membrane hyperpolarization and nitric oxide production in human vascular endothelial cells. Cell Calcium 49:240.

[2] Golan et al. (2011) Extracellular nucleotide derivatives protect cardiomyocytes against hypoxic stress. Biochemical Pharmacology 81:1219.

[3] Boucher et al. (2011) Distinct activation of epidermal growth factor receptor by UTP contributes to epithelial cell wound repair. American Journal Pathology 178:1092.

[4] Sugihara et al. (2011) Dual signaling pathway of arterial constriction by extracellular uridine-5-triphosphate in the rat. J. Pharmacological Sciences (Japan) 115:293.

[5] Ma et al. (2011) Molecular cloning and analysis of the UDP-glucose pyrophosphorylase in Streptococcus equi subsp. Zooepidemicus. Molecular Biology Reports 38:2751.

[6] Delic et al. (2011) Nucleotides affect neurogenesis and dopaminergic differentiation of mouse fetal midbrain-derived neural precursor cells. Puronergic Signalling 6:417.

[7] Jiang et al. (2011) Biochemical characterization of enterovirus 71 3D RNA polymerase. Biochim. Biophys. Acta, Gene Regulatory Mechanisms 1809:211.

[8] Pendergast et al. (2001) Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates. Bioorg. Med. Chem. Lett. 11 (2):157.

[9] Shaver et al. (1997) 4-substituted uridine 5'-triphosphates as agonists of the P2Y2 purinergic receptor. Nucleosides and Nucleotides 16 (7):1099.

[10] Kim et al. (2002) Methanocarba modification of uracil and adenine nucleotides: High potency of northern ring conformation at P2Y1, P2Y2, P2Y4 and P2Y11 but not P2Y6 receptors. J. Med. Chem. 45:208.

[11] Nguyen et al. (1995) Cloning, expression, and chromosomal localization of human uridine nucleotide receptors. J. Biol. Chem. 270 (52):30845.