PTP 1B
Protein Tyrosine Phosphatase 1B
human, recombinant, E. coli
| Catálogo Nº | Apresentação | Preço (R$) | Comprar / Observação |
|---|---|---|---|
| PR-931 | 20 μg | Sob demanda | Adicionar ao Carrinho |
For general laboratory use.
Envio: shipped on dry ice
Condições de armazenamento: store at -80 °C
avoid freeze/thaw cycles
Validade: 12 months
Peso molecular: 37.3 kDa
Número de acesso: NP_002818
Número de acesso: NP_002818
Pureza: > 90 % (SDS-PAGE)
Forma: liquid (Supplied in 50 mM HEPES pH 7.4, 40 mM NaCl, 1 mM EDTA, 1 mM DTT and 2 mM beta-Mercaptoethanol)
Atividade: 1 nmol of PTP 1B will hydrolyze 37 nmol of pNPP per minute at 30°C.
Descrição:
PTP 1B is the prototype nontransmembrane protein tyrosine phosphatase. It is a ubiquitous protein that was originally identified in human placenta. This highly active enzyme is well suited for the study of tyrosine phosphatase kinetics and substrate specificity, as well as for the screening of inhibitors.
Referências selecionadas:
Montalibet et al. (2004) Using yeast to screen for inhibitors of protein tyrosine phosphatase 1B. Biochem. Pharmacol. 68:1807.
Puius et al. (1997) Identification of a second aryl phosphatebinding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. Proc. Natl. Acad. Sci. USA. 94:13420.
Liu et al. (1996) Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130 (Cas). J. Biol. Chem. 271:31290.