Ran - E70A
Ras-related nuclear protein, TC4
human, recombinant, E. coli
| Catálogo Nº | Apresentação | Preço (R$) | Comprar / Observação |
|---|---|---|---|
| PR-215 | 50 μg | Sob demanda | Adicionar ao Carrinho |
For general laboratory use.
Envio: shipped on dry ice
Condições de armazenamento: store at -80 °C
avoid freeze/thaw cycles
Validade: 12 months
Peso molecular: 24.0 kDa (216 amino acids)
Número de acesso: NM_006325
Número de acesso: NM_006325
Pureza: > 90 % (SDS-PAGE)
Forma: liquid (Supplied in 20 mM KH2PO4/K2HPO4 pH 7.4, 1 mM DTE and 5 mM MgCl2)
Descrição:
Ran (Ras-related nuclear protein, TC4) belongs to the Ras superfamily of GTP binding proteins. It acts in cellular processes such as nuclear transport, mitotic spindle assembly, and post-mitotic nuclear assembly. The mutation E70A results in inhibition of the guanine exchange reaction mediated by RCC1, the guanine nucleotide exchange factor (GEF) for Ran. Protein preparation is 85% GDP-loaded, measured by HPLC.
Referências selecionadas:
Dasso (2002) The Ran GTPase: Theme and Variations. Current Biology 12:502. Renault et al. (2001) Structural Basis for Guanine Nucleotide Exchange on Ran by the regulator of Chromosome Condensation (RCC1). Cell 105:245.