TG MIC3 (residues 234-306)

For general laboratory use.

Envio: shipped on gel packs

Condições de armazenamento: store at -20 °C
avoid freeze/thaw cycles

Validade: 12 months

Pureza: > 95 % (SDS-PAGE)

Forma: liquid (Supplied in 50 mM Tris-HCl pH 8.0, 1.5 M urea and 0,1 mM EDTA)

Formulários:
Antigen in ELISA and Western blots, excellent antigen for detection of Toxoplasma gondii with minimal specificity problems.

Descrição:
The protein contains the Toxoplasma gondii MIC3 immunodominant regions, amino acids 234-306. The protein is purified by proprietary chromatographic technique.

Background: Toxoplasma gondii is an obligate intracellular protozoan parasite that infects all warmblooded animals, including humans, and causes toxoplasmosis. The homodimeric micronemal protein MIC3, which is a potent adhesin molecule of T. gondii, could be a significant candidate vaccine against toxoplasmosis.

Specificity: Immunoreactive with sera of T. gondii- infected individuals.

Referências selecionadas:
Ismael et al. (2003) The MIC3 gene of Toxoplasma gondii is a novel potent vaccine candidate against toxoplasmosis. Infect. Immun. 71:6222.

Cerede et al. (2002) The Toxoplasma gondii protein MIC3 requires pro-peptide cleavage and dimerization to function as adhesin. EMBO J. 21:2526.

Garcia-Reguet et al. (2000) The microneme protein MIC3 of Toxoplasma gondii is a secretory adhesin that binds to both the surface of the host cells and the surface of the parasite. Cell. Microbiol. 2:353.