Human Papillomavirus 16 GST

For general laboratory use.

Envio: shipped on gel packs

Condições de armazenamento: store at -20 °C
avoid freeze/thaw cycles

Validade: 12 months

Pureza: > 95 % (SDS-PAGE)

Forma: liquid (Supplied in PBS, 100 mM K2CO3 and 5 M urea)

Descrição:
The Recombinant HPV-16 antigen is a full length protein expressed in E. coli having an MW of 56.7 kDa. The protein is fused to a 26 kDa GST-Tag.
Human papillomaviruses (HPVs) are a group family with more than 150 related viruses. HP 6 and 11 considered as low-risk HPVs can be sexually transmitted, causing warts to emerge on or around the genitals or anus, known as condylomata acuminate. HPV-6 major/large capsid antigen is used in clinical diagnosis to test the specific antibody to this virus induced by the virus infection, the positive reaction of this antibody is deemed as a marker for present and past infection. Furthermore, HPV-6 large capsid is used as a potential candidate for vaccine development.

Amino Acid Sequence:
MQVTFIYILV ITCYENDVNV YHIFFQMSLW LPSEATVYLP PVPVSKVVST DEYVARTNIY YHAGTSRLLA VGHPYFPIKK PNNNKILVPK VSGLQYRVFR IHLPDPNKFG FPDTSFYNPD TQRLVWACVG VEVGRGQPLG VGISGHPLLN KLDDTENASA YAANAGVDNR ECISMDYKQT QLCLIGCKPP IGEHWGKGSP CTNVAVNPGD CPPLELINTV IQDGDMVHTG FGAMDFTTLQ ANKSEVPLDI CTSICKYPDY IKMVSEPYGD SLFFYLRREQ MFVRHLFNRA GTVGENVPDD LYIKGSGSTA NLASSNYFPT PSGSMVTSDA QIFNKPYWLQ RAQGHNNGIC WGNQLFVTVV DTTRSTNMSL CAAISTSETT YKNTNFKEYL RHGEEYDLQFI FQLCKITLTA DVMTYIHSMN STILEDWNFG LQPPPGGTLE DTYRFVTQAI ACQKHTPPAP KEDDPLKKYT FWEVNLKEKF SADLDQFPLG RKFLLQAGLK AKPKFTLGKR KATPTTSSTS TTAKRKKRKL

Referências selecionadas:
Munoz et al. (2010) Impact of human papillomavirus (HPV)-6/11/16/18 vaccine on all HPV-associated genital diseases in young women.J Natl Cancer Inst. 102:325.