HIV-2 Envelope

For general laboratory use.

Envio: shipped on gel packs

Condições de armazenamento: store at -20 °C
avoid freeze/thaw cycles

Validade: 12 months

Pureza: > 97 % (SDS-PAGE, RP-HPLC)

Forma: liquid (Supplied in 50 mM Tris-HCl pH 7.2 and 6 M urea)

Descrição:
This antigen is an E. coli-derived recombinant protein that composes all of the reported immunogenic determinants found in gp36. The gene encoding this fusion protein was synthesized using codons optimized for E. coli expression and doesn't represent a linear HIV-2 envelope sequence. rHIV-2 is a non-glycosylated, 135 amino acid polypeptide chain, having a molecular mass of 16.1 kDa. Recombinant HIV-2 Envelope is purified by proprietary chromatographic technique.

Background: HIV belongs to the retrovirus family, distinguished by possession of a viral reverse transcriptase that transcribes viral RNA into DNA which is integrated into the host-cell genome. gp36 is the transmembrane envelope protein from HIV-2 comparable to gp41 from HIV-1.

Endotoxin: Less than 0.1 ng/μg (IEU/μg) of HIV-2 Envelope.

Referências selecionadas:
Chen et al. (1995) HIV-2 transmembrane protein gp36 like HIV-1 gp41 binds to human lymphocytes and monocytes. AIDS. 9:1193.