NPE-caged-AppNHp
(NPE-caged-AMPPNP)
Adenosine-5'-[( β,γ )-imido]triphosphate, P3-(1-(2-nitrophenyl)-ethyl)-ester, Triethylammonium salt
| Catálogo Nº | Apresentação | Preço (R$) | Comprar |
|---|---|---|---|
| NU-305S | 20 μl (10 mM) | Sob demanda | Adicionar ao Carrinho |
| NU-305L | 5 x 20 μl (10 mM) | Sob demanda | Adicionar ao Carrinho |
![Structural formula of NPE-caged-AppNHp ((NPE-caged-AMPPNP), Adenosine-5'-[( β,γ )-imido]triphosphate, P3-(1-(2-nitrophenyl)-ethyl)-ester, Triethylammonium salt)](/images/Structures/NU-305.png)
For general laboratory use.
Envio: shipped on gel packs
Condições de armazenamento: store at -20 °C
store dark
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Validade: 6 months after date of delivery
Fórmula molecular: C18H24N7O14P3 (free acid)
Peso molecular: 655.35 g/mol (free acid)
CAS#: 116271-21-7
Pureza: ≥ 95 % (HPLC)
Forma: solution in water
Concentração: 10 mM - 11 mM
pH: 7.5 ±0.5
Propriedades espectroscópicas: λmax 260 nm, ε 18.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Formulários:
Agonistic ligand, mainly for nucleoside receptor A1
Nucleosidephosphates stabilized against hydrolytic degradation can directly bind to nucleoside receptors. The caged form is protected during uptake and transport in animal experiments and can be well-directed released through activation at the target tissue.
Referências selecionadas:
Volonte et al. (2009) Membrane components and purinergic signalling: the purinome, a complex interplay among ligands, degrading enzymes, receptors and transporters. FEBS J. 276:318.
Yegutkin (2008) Nucleotide and nucleoside converting enzymes: Important modulators of purinergic signalling cascade. Biochim. Biophys. Acta 1783:673.
Williams et al. (1986) Effects of purine nucleotides on the binding of [3H]cyclopentyladenosine to adenosine A1-receptors in rat brain membranes. J. Neurochem. 47 (1):88.