5-Formyl-dC
fdC, 5-Formyl-2'-deoxycytidine
| Catálogo Nº | Apresentação | Preço (R$) | Comprar / Observação |
|---|---|---|---|
| N-1069-5 | 5 mg | Sob demanda | Adicionar ao Carrinho |
For research use only!
Envio: shipped at ambient temperature
Condições de armazenamento: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Validade: 24 months after date of delivery
Fórmula molecular: C10H13N3O5
Peso molecular: 255.23 g/mol
CAS#: 137017-45-9
Pureza: ≥ 95 % (HPLC)
Forma: solid
Propriedades espectroscópicas: λmax 283 nm, ε 11.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Formulários:
Epigenetic research[1]
Use in epigenetic therapy[2]
Metabolism of dC substituted at position 5[3,4]
Referências selecionadas:
[1] Schroeder (2014) Synthesis of a DNA promoter segment containing all four epigenetic nucleosides: 5-Methyl-, 5-hydroxymethyl-, 5-formyl-, and 5-carboxy-2'-deoxycytidine. Angew. Chem. Int. Ed. 53:315.
[2] Zauri et al. (2015) CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer. Nature 524:114.
[3] Schiesser et al. (2013) Deamination, oxidation, and C-C bond cleavage reactivity of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine. J. Am. Chem. Soc. 135 (39):14593.
[4] Madugundu et al. (2014) Hydroxyl-radical-induced oxidation of 5-methylcytosine in isolated and cellular DNA. Nucleic Acids Res. 42 (11):7450.