THPTA
Tris((1-hydroxy-propyl-1H-1,2,3-triazol-4-yl)methyl)amine
| Catálogo Nº | Apresentação | Preço (R$) | Comprar |
|---|---|---|---|
| CLK-1010-25 | 25 mg | Sob demanda | Adicionar ao Carrinho |
| CLK-1010-100 | 100 mg | Sob demanda | Adicionar ao Carrinho |
| CLK-1010-1G | 1 g | Sob demanda | Adicionar ao Carrinho |
For general laboratory use.
Envio: shipped at ambient temperature
Condições de armazenamento: store at 4 °C
Validade: 12 months after date of delivery
Fórmula molecular: C18H30N10O3
Peso molecular: 434.50 g/mol
CAS#: 760952-88-3
Pureza: ≥ 95 % (HPLC)
Forma: solid
Solubilidade: water, DMSO, DMF, MeOH
Descrição:
THPTA is a water-soluble, very effective ligand for Cu(I)-catalyzed Alkyne-Azide click chemistry reactions (CuAAC). It serves a dual purpose: 1) Accelaration of the CuAAC reaction by maintaining the Cu(I) oxidation state of copper sources and 2) Protection of biomolecules from oxidative damage during the labeling reaction[1,2].
THPTA is a superior alternative to water-insoluble TBTA.
A stock solution can be prepared in ddH2O and subsequently be stored at -20°C. Avoid freeze-thaw cycles.
Presolski et al.[1] and Hong et al.[2] provide a general protocol for CuAAC reactions that may be used as a starting point for the set up and optimization of individual assays.
Produtos relacionados: Copper (II)-Sulphate (CuSO4), #CLK-MI004 Sodium Ascorbate (Na-Ascorbate), #CLK-MI005 THPTA, #CLK-1010 BTTAA, #CLK-067
Referências selecionadas:
[1] Presolski et al. (2011) Copper-Catalyzed Azide-Alkyne Click Chemistry for Bioconjugation. Current Protocols in Chemical Biology 3:153.
[2] Hong et al. (2011) Analysis and Optimization of Copper-Catalyzed Azide-Alkyne Cycloaddition for Bioconjugation. Angew. Chem. Int. Ed. 48:9879.